2022.01.24 07:37 Bonus1Fact [News Shorts] Omicron variant could spell 'end of the pandemic': O'Neill ¦ Sky News Australia
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2022.01.24 07:37 castoff-filth This is all Josh Allens fault all he had to do was pick heads
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2022.01.24 07:37 29996 My very own Ork "ancient"
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2022.01.24 07:37 Ricosss Metabolic Adaptions/Reprogramming in Islet Beta-Cells in Response to Physiological Stimulators—What Are the Consequences (Pub Date: 2022-01-01)
Metabolic Adaptions/Reprogramming in Islet Beta-Cells in Response to Physiological Stimulators—What Are the Consequences Abstract Irreversible pancreatic β-cell damage may be a result of chronic exposure to supraphysiological glucose or lipid concentrations or chronic exposure to therapeutic anti-diabetic drugs. The β-cells are able to respond to blood glucose in a narrow concentration range and release insulin in response, following activation of metabolic pathways such as glycolysis and the TCA cycle. The β-cell cannot protect itself from glucose toxicity by blocking glucose uptake, but indeed relies on alternative metabolic protection mechanisms to avoid dysfunction and death. Alteration of normal metabolic pathway function occurs as a counter regulatory response to high nutrient, inflammatory factor, hormone or therapeutic drug concentrations. Metabolic reprogramming is a term widely used to describe a change in regulation of various metabolic enzymes and transporters, usually associated with cell growth and proliferation and may involve reshaping epigenetic responses, in particular the acetylation and methylation of histone proteins and DNA. Other metabolic modifications such as Malonylation, Succinylation, Hydroxybutyrylation, ADP-ribosylation, and Lactylation, may impact regulatory processes, many of which need to be investigated in detail to contribute to current advances in metabolism. By describing multiple mechanisms of metabolic adaption that are available to the β-cell across its lifespan, we hope to identify sites for metabolic reprogramming mechanisms, most of which are incompletely described or understood. Many of these mechanisms are related to prominent antioxidant responses. Here, we have attempted to describe the key β-cell metabolic adaptions and changes which are required for survival and function in various physiological, pathological and pharmacological conditions.
------------------------------------------ Info ------------------------------------------
Open Access: True (not always correct)
Authors: * Philip Newsholme * Jordan Rowlands * Roselyn Rose’Meyer * Vinicius Cruzat
Additional links: * https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773416
submitted by Ricosss to ketoscience [link] [comments]
2022.01.24 07:37 Professional-Face345 Can you end up the dragonborn dlc without killing miraak ?
2022.01.24 07:37 Positive-Ad9922 Frosty day in Florida
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2022.01.24 07:37 RuthlessGenetics Question about germination.
So I’m about to start my first grow but I’m very confused on one thing, once my seeds germinate and are ready to be transplanted into their medium , do I need to use a weak light? Or can I use my 480watt FC -4800 LED and just turn it all the way down?
submitted by RuthlessGenetics to CannabisGrowers [link] [comments]
2022.01.24 07:37 Few-Hall6884 I’m fleece lingerie
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2022.01.24 07:37 loragoblack Copy and paste text into CSGO on Linux
This is a bit of a weird one, but usually when I am on Windows.. I like to open the Steam overlay when I am in CSGO and copy translated sentences from Google using the overlay web browser and paste it into the game chat.
On Linux, however, this is not possible. I am able to copy and paste text into the browser and everywhere else, but when I try to paste into the game chat nothing happens.
I hope this made sense. Does anyone have an idea as to what could be preventing this? Could it be like a clipboard sharing between a VM and a host machine like something needs to be enabled for cross sharing to work?
submitted by loragoblack to linux_gaming [link] [comments]
2022.01.24 07:37 pugnacious_wanker SRT file does not work when streaming video to iPad
I’m streaming video from PC to iPad. I have a .mkv file and a .srt file in the same shared folder, they are exactly the same filename. In the iOS VLC app only the .mkv file is visible. When streaming the .mkv file, I choose Track 1 from the subtitle box, and nothing happens. No subtitles. How is this possible?
submitted by pugnacious_wanker to VLC [link] [comments]
2022.01.24 07:37 hannes3120 [Titanium White Fennec] [Titanium White Interstellar] [Titanium White Phase-R] [Titanium White Jak'd: Obverse] [Titanium White Fissure]
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2022.01.24 07:37 KindAd3928 Should I become a nurse?
Im sure this has already been posted many times but I am having a small existential crisis and I just gotta know…
I currently work as a vet tech at a 24hr emergency animal hospital. I’ve been thinking that I’d like to go into human nursing as I feel like there’s a lot more room for growth/ so many different avenues to go down compared to being a vet nurse. Im used to working Night Shifts and other weird hours, and although I don’t love it I think I would be ok with it if i felt like I was making a positive difference to peoples lives. Other than that I don’t mind the stressful work environment or blood etc.
But almost everyone I speak to tells me I’m making a mistake and that nursing sucks so I guess I just wanna hear what some actual nurses think.
submitted by KindAd3928 to nursing [link] [comments]
2022.01.24 07:37 JobHuntersMod1 CYBERSECURITY Jobs & Paid Internships
Hi JobHunters! If you are looking for entry-level remote Cybersecurity roles, please check out the latest posts on The Remote JobHunters' job board below:
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2022.01.24 07:37 freereadingtarot Why I hate Rengoku Gaiden?
As you all know, Rengoku Gaiden is mangaka Ryouji Hirano's work and was accepted by Gotouge to post on Weekly Jump. But for all you who still didn't read it yet, then I have an advice: "If you want to read it, then read it just for fun only, don't combine it with original work." And those are reason why I hate it:
2022.01.24 07:37 Jack_o_lanterns Japanese horror poem gf
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2022.01.24 07:37 Now-that-is-a-zoot Hair thinning but still getting new growth
I’ve recently started dut after 1 year and a half of fin. Been on min the same length of time.
I’ve started seeing new hair growth around the temples yet overall scalp hair appears to still be thinning.
Is it possible for hair to still thin whilst still getting new growth?
I’m not diffuse thinning however appreciate that it may be a dut shed after switching medication
submitted by Now-that-is-a-zoot to tressless [link] [comments]
2022.01.24 07:37 Sancroth_2621 Filebeat autodiscover on k8s
Recently i got a new job in pure devops.
Lads here work mainly on k8s clusters. I have been tasked with creating network policies to secure all pods as much as possible and this led me to a few monitoring pods, like filebeat.
I come from a sysadmin background so i do have experience with beats and ELK, but bare metal style. So a filebeat service per server configured properly to handle server and app logs.
Here they are deploying a daemon set which spawns a filebeat pod per node, mounts /valog and container logs, /valib/dockecontainers and uses autodiscover.
Now this is the part that bugs me and i do not understand. How does the kubernetes provider autodiscover works? The way i see it right now, on these setups, is that each filebeat pod works the same way as a bare metal works. it monitors and parses all logs found under:
on it's perspective node(daemon set).
2022.01.24 07:37 Weird_Platform6144 One of these or baby torres (untradable) next to mid cruyff?
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2022.01.24 07:37 Few_Ice_6576 i love rainy season 😌 ❤🌧
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2022.01.24 07:37 CheckLow3236 Join my Live Group "THE HANGBANG (w/Evie)", ONLY valid for 24h.
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2022.01.24 07:37 optionhome The so typical White female Liberal moron
|submitted by optionhome to ConservativeMemes [link] [comments]|
2022.01.24 07:37 Appropriate_Result30 Really confused. Advice welcome
I had a pretty bad break up last year with someone I’m starting to realize is a narcissist. I was pretty traumatized but I’m working on healing from it. I have had a friend for 8 years (since we were 18) and I call him from time to time to talk. He was really one of the only people my ex didn’t try to stop me from staying in touch with.
Anyways, I called him to vent a bit and catch up and I discussed my recent revelation. He didn’t seem very responsive so I just brought up some examples and ended up saying I should have known it would be bad when he refused to be friends if I wouldn’t date him… well, it brought up a conversation with my friend about how he asked if there was anything between us 6 years ago and when I said no he dropped it and stayed friends. He told me it was because he valued me as a friend and knew either way he wanted to stay in my life and clearly my ex didn’t. Everything seemed fine but suddenly he sort of starts to say mean things to me. He told me I was socially awkward because after I was traumatized by this break up and I went to a party with him and his girlfriend I sort of ranted to them and 2 of their friends about it… but it was right after it happened and I actually ended up staying friends with them after that night so clearly it wasn’t that bad.
Then he told me I was one of the most type A people he has ever met and I was mean. He didn’t give me examples other than the fact I took over a class project and got everyone an A in college- which he always acted thankful for in the past. It really came out of nowhere and I’m really hurt and self conscious now. Im just really second guessing myself. Do you all think he was just hurt and striking out? Or should I really be concerned? I feel like someone that thinks I’m such an awful/awkward person wouldn’t stay friends with me for this long? I’m truly trying to think of anything that could be a problem. 2 months ago he was having troubles with work and wanted to apply to be my secretary before he figured things out with his job. I really couldn’t imagine trying to work for someone I thought was like that. I’m so lost
submitted by Appropriate_Result30 to relationship_advice [link] [comments]
2022.01.24 07:37 PavloPub Multiple input languages using physical keyboard and GBoard - is it possible?
Since years, there were difficulties using non-Samsung keyboard in Dex. Though, for some time it's possible to enable GBoard in Dex.
However, I still can't figure out how to configure multiple languages and switching between them smoothly for combination of dex+gboard+physical KB. OneUI 4, Android 12.
Though I do have inp.lang. switching enabled (Shift+space, shift+alt,...), none of them works.
And I suspect due to the fact I can select only one language in physical KB settings. At least when I open physical KB settings, I can change input language, but I don't see any option to "enable" multiple input languages. I also do see both GBoard and Smaung KB under my physical KB settings, I dunno if that's "OK".
Is it working for anyone here? How have you configured it?
submitted by PavloPub to SamsungDex [link] [comments]
2022.01.24 07:37 Gerard192021 My Thoughts when Monique renamed herself “Mo Heart”:
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2022.01.24 07:37 chrisztech Mutually exclusive cells on multiple sheets from a list of entries
Hopefully someone can help.
Basically on one sheet I want to be able to add a list of data in to a column, remove any duplicates (easy bit) then on different sheets pick from that list, but they must be mutually exclusive.
sheet1 a1= value 1, a2=value 2, etc
sheet2 pick from list in sheet1 , b3= a1 (value 1)
sheet3 pick from list in sheet1, b3= a2 (value 2), but not allow you to enter value 1
the idea being a list of inputs on sheet 1 can be used to populate other sheets, without repetition or other duplicates.
submitted by chrisztech to excel [link] [comments]